Zip Nucleic Acids (ZNA®) are novel modified oligonucleotides enhancing hybridization properties of nucleic acids. ZNA® are oligonucleotides conjugated to cationic units. ZNA® show increased affinities for their targets by reducing the electrostatic repulsion between nucleic acid strands. ZNA® increase both the binding efficiency and the kinetic, and stabilize the hybridization to their target, making them very efficient especially as PCR and Q-PCR primers and probes. These properties make ZNA® promising powerful tools for molecular biology and diagnostic applications.
More information on the ZNA® product page.