STICKY SIRNA is a new class of interfering RNAs for Therapeutics application. They have been designed to dramatically enhance siRNA-mediated gene silencing in vivo. STICKY SIRNA has a high RNA interference activity in eukaryotic cells and provides higher gene silencing efficiencies than those obtained using conventional siRNA, when introduced with the same delivery system. The modification carried by these oligos significantly increases the siRNA and formulation stability, in vivo delivery, RNase protection and gene silencing without inducing pro-inflammatory cytokine responses.
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