Summary

Meet our Team at booth #569 and listen to our Tools and Technology Forum Presentation on May 16 !

Our team

 Mathieu Porte 
 Bioproduction R&D Manager  
About Mathieu Porte
Bioproduction R&D Manager
Aucune information.
 Brian Bulsak 
 Sales Specialist - Mid-Atlantic 
About Brian Bulsak
Sales Specialist - Mid-Atlantic
Aucune information.
 Geraldine Guerin-Peyrou 
 Director of Marketing & Communication 
About Geraldine Guerin-Peyrou
Director of Marketing & Communication
Aucune information.
 Tom KRESGE 
 VP Sales US 
About Tom KRESGE
VP Sales US
Aucune information.

Talk: Next-Generation Transfection Reagent for Large Scale AAV Manufacturing

The number of ATMP therapeutic-based medicines for inherited genetic disorders is in constant growth, with a global 32% increase in new clinical trials in the last 4 years. ATMPs have demonstrated their success with already more than ten approved for commercialization. The success of AAV as the most promising viral vector for gene therapy is due to low immunogenicity, broad tropism and non-integrating properties. One major challenge for translation of promising research to clinical development is the manufacture of sufficient quantities of AAV.

Transient transfection of suspension cells is the most commonly used production platform, as it offers significant flexibility for cell and gene therapy development. However, this method presents some limitations in large scale bioreactors: inadequate transfection protocol, reduced transfection efficiency and lower productivity. To address this concern, we present data on a novel transfection reagent showing: I) increased AAV titers, II) improved transfection protocol for large scale bioreactors, III) reproducibility of viral titers at different production scale and IV) customer data. The aforementioned optimized parameters make this novel transfection reagent ideal for cell and gene therapy developers by combining the flexibility of transient transfection with scalability and speed to market.

Presented by Mathieu PORTE, R&D Bioproduction Manager at Polyplus®

Monday May 16th from 3:45 pm – 4:00 pm ET at Tools and Technology Forum.

Poster

Next-Generation Transfection Reagent for Large Scale AAV Manufacturing

Mathieu Porte, Mégane Denu, Jonathan Havard, Marine Ricordel, Coralie Stritt, Yann Philipson, Malik Hellal, Patrick Erbacher

Our solutions for viral vector production

FectoVIR®-AAV

FectoVIR®-AAV

PEIpro® Product range

ASGCT 25th Annual Meeting general information

Registration link for virtual event: click here
Give your feedback!