Meet our Team at Bioproduction Congress booth #30, in Lyon, September 30 - October 1, 2021

Our team

 Jean-Thomas ISSENHUTH 
 Key Account Manager 
About Jean-Thomas ISSENHUTH
Key Account Manager
Aucune information.
 Younes BOULILA 
 Business Manager 
About Younes BOULILA
Business Manager
Aucune information.


Next-Generation Transfection Reagent for Large Scale AAV Manufacturing.

The number of ATMP therapeutic-based medicines for inherited genetic disorders is in constant growth, with a global 32% increasein new clinical trials in the last 4 years. ATMPs have demonstrated their success with already more than ten approved for commercialization. The success of AAV as the most promising viral vector for gene therapy is due to low immunogenicity, broad tropism and non-integrating properties. One major challenge for translation of promising research to clinical development is the manufacture of sufficient quantities of AAV. Transient transfection of suspension cells is the most commonly usedproduction platform, as it offers significant flexibility for cell and gene therapy development. However, this method presents some limitations in largescale bioreactors: inadequate transfection protocol, reduced transfection efficiency and lower productivity. To address this concern, we present data on a novel transfection reagent showing: i) increased AAV titers, ii) improved transfection protocol for large scale bioreactors and iii) reproducibility of viral titers at different production scale. The aforementioned optimizedparameters make this novel transfection reagent ideal for cell and gene therapy developers by combining the flexibility of transient transfection with scalability and speed to market.

Presented by Jean-Thomas Issenhuth, Key Account Manager, at Polyplus-transfection.


Our solutions for both protein and virus production

FectoVIR®-AAV: for Recombinant AAV virus production in suspension cells.

PEIpro® product range for a scalable viral vector production for Gene & Cell therapy.


General information

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103 Boulevard de Stalingrad
69100 Lyon, France
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