- Authors: Coller JB. et al.
- Year: 2019
- Journal: Cell Mol Life Sci
- Applications: in vivo / miRNA / in vivo-jetPEI
Complexation by vortexing and 15-20 min RT.
Prior studies have established the important role of extracellular signal-regulated kinase 1/2 (ERK1/2) as a mediator of acute kidney injury (AKI). We demonstrated rapid ERK1/2 activation induced renal dysfunction following ischemia/reperfusion (IR)-induced AKI and downregulated the mitochondrial biogenesis (MB) regulator, peroxisome proliferator-activated receptor