Citation
- Authors: Liu, L., Siu, F. M., Che, C. M., Xu, A., Wang, Y.
- Year: 2012
- Journal: Am J Transl Res
- Applications: in vitro / siRNA / jetPEI
- Cell types:
- Name: HEK-293
Description: Human embryonic kidney Fibroblast
Known as: HEK293, 293 - Name: MDA-MB-231
Description: Human breast adenocarcinoma cells
Known as: MDAMB231
- Name: HEK-293
Abstract
The survival kinase Akt and the tumor suppressor LKB1 elicit opposite effects on cell proliferation and tumorigenesis. The present study demonstrates that Akt acts as an upstream kinase of LKB1 to promote the phosphorylation at Ser334 and facilitate its binding to 14-3-3 proteins, resulting in a decreased interaction with STE20-related adaptor protein