Citation

  • Authors: Liu, L., Siu, F. M., Che, C. M., Xu, A., Wang, Y.
  • Year: 2012
  • Journal: Am J Transl Res
  • Applications: in vitro / siRNA / jetPEI
  • Cell types:
    1. Name: HEK-293
      Description: Human embryonic kidney Fibroblast
      Known as: HEK293, 293
    2. Name: MDA-MB-231
      Description: Human breast adenocarcinoma cells
      Known as: MDAMB231

Abstract

The survival kinase Akt and the tumor suppressor LKB1 elicit opposite effects on cell proliferation and tumorigenesis. The present study demonstrates that Akt acts as an upstream kinase of LKB1 to promote the phosphorylation at Ser334 and facilitate its binding to 14-3-3 proteins, resulting in a decreased interaction with STE20-related adaptor protein