in vivo-jetPEI® is the leading in vivo delivery method with a proven track record of over 700 publications. in vivo-jetPEI® is an injectable polymer-based in vivo transfection reagent that was developed with the following objectives: easiness of use, efficiency and versatility. It is a cationic polymer composed of PEI that efficiently encapsulates and protects nucleic acids by forming less than 100 nm nanoparticles that efficiently penetrate in the tissue to reach targeted cells.
in vivo-jetPEI® product range is composed of three quality grade in vivo transfection reagents that are directly injectable: Research grade in vivo-jetPEI® for in vivo functional studies and proof of concept studies of nucleic acid mediated therapies; in vivo-jetPEI®-PC for preclinical safety, toxicology, and biodistribution studies; and highest quality grade GMP in vivo-jetPEI® for Human clinical trials (Table 1).
Table 1: Range of in vivo-jetPEI® quality grade reagents for each step of nucleic acid-mediated non-viral vector-based manufacturing. in vivo-jetPEI® is available as an R&D grade for fundamental research and proof of concept studies. For preclinical biodistribution and toxicology studies and early phase clinical studies, we supply a higher preclinical grade in vivo-jetPEI®. GMP in vivo-jetPEI® is the highest quality grade available to meet quality demands in Human clinical trials.
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