SIRNAPLUS™ are a class of self-delivering, cationic siRNA duplexes, composed of an antisense sequence annealed to an oligospermine conjugated sense strand. There is a burining need for molecules which can safely and effective enter living cells – SIRNAPLUS™ are the solution for siRNA delivery.

• Innovative molecules – a real alternative to nanoparticles
• Classical building block online synthesis
• No formulation requirements
• Defined drug entity presenting classical pharmacology
• Specific gene silencing activity at low nanomolar concentration
• RISC mediated mechanism
• Stable in serum

Voirin, E., Behr, JP. and Kotera M. (2007) Versatile synthesis of oligodeoxyribonucleotide-oligospermine conjugates. Nat Protoc, 2, 1360-1367.

Nothisen, M., Kotera, M., Voirin, E., Remy, JS. and Behr JP. (2009) Cationic siRNAs provide Carrier-free gene silencing in animal cells. J. Am. Chem. Soc., 131, 17730-17731.

Patent #WO 2009095887, for which Polyplus-transfection^® is the worldwide exclusive licensee.