Polyplus’ Expertise: Transfection
Transfection allows the introduction of nucleic acids, such as a gene or small interfering RNA (siRNA), into cells using chemical compounds. The technique is widely used in experimental research and in recombinant protein production.
Introducing a gene into a cell nucleus triggers the expression of the corresponding protein. Conversely, transferring siRNA will block the production of a protein.
Mechanism of DNA and siRNA transfection in Eukaryotic cells
Inappropriate gene expression is at the root of numerous diseases. As a result, the ability to control gene expression through gene therapy or RNA interference opens up new therapeutic approaches where efficient intracellular drug transfer is key to success.
Using its know-how in nucleic acid delivery, the R&D department at Polyplus-transfection is focused on the development of innovative compounds designed to take account of the latest advances in the transfer of biomolecules, especially the in vivo delivery of small interfering RNA. Polyplus-transfection is one of the technology leaders of the transfection market.
