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Publications from the Polyplus Team

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Paris, C., Moreau, V., Deglane, G., Karim, L., Couturier, B., Bonnet, M.E., Kedinger, V., Messmer, M., Bolcato-Bellemin, A.L., Behr, J.P., Erbacher, P., Lenne-Samuel, N. (2012). Conjugating Phosphospermines to siRNAs for Improved Stability in Serum, Intracellular Delivery and RNAi-Mediated Gene Silencing. Mol Pharm.

Nothisen, M., Kotera, M., Voirin, E., Remy, JS. and Behr JP. (2009) Cationic siRNAs provide Carrier-free gene silencing in animal cells. J. Am. Chem. Soc., 131, 17730-17731.


Bolcato-Bellemin, A. L., Bonnet, M. E., Creusat, G., Erbacher, P., and Behr, J. P. (2007). Sticky overhangs enhance siRNA-mediated gene silencing. Proc Natl Acad Sci U S A 104, 16050-16055.

Bonnet, M. E., Gossart, J. B., Benoit, E., Messmer, M., Zounib, O., Moreau, V., Behr, J. P., Lenne-Samuel, N., Kedinger, V., Meulle, A., Erbacher, P. and Bolcato-Bellemin, A. L. (2013). Systemic delivery of sticky siRNAs targeting the cell cycle for lung tumor metastasis inhibition. J Control Release 10;170(2):183-90

Kedinger V, Meulle A, Zounib O, Bonnet ME, Gossart JB, Benoit E, Messmer M, Shankaranarayanan P, Behr JP, Erbacher P, Bolcato-Bellemin A.L. (2013). Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases. BMC Cancer., 13(1):338.


Turner, J. (2012) Spermine phosphoramidite: a potent modification with many applications, The Glen Report, 24, 1, 1-4. Download the PDF

Paris, C., Moreau, V., Deglane, G., Voirin, E., Erbacher, P. and Lenne-Samuel, N. (2010) Zip nucleic acids are potent hydrolysis probes for quantitative PCR. Nucl. Acids Res., 38: e95. Download the PDF

Nothisen, M., Kotera, M., Voirin, E., Remy, JS. and Behr JP. (2009) Cationic siRNAs provide Carrier-free gene silencing in animal cells. J. Am. Chem. Soc., 131, 17730-17731.

Moreau, V., Voirin, E., Paris, C., Kotera, M., Nothisen, M., Remy, J-S., Behr, J-P.,  Erbacher, P. and Lenne-Samuel, N.,. (2009). Zip nucleic acids (ZNAs): new high affinity oligonucleotides as potent primers for PCR and reverse transcription. Nucl. Acids Res., 37: e130. Download the PDF

Noir, R., Kotera, M., Pons, B., Remy, JS., and  Behr, JP. (2008) Oligonucleotide-oligospermine conjugates (Zip Nucleic Acids): a convenient means of finely tuning hybridization temperatures. J Am Chem Soc, 130, 13500-13505.

Voirin, E., Behr, JP. and Kotera M. (2007) Versatile synthesis of oligodeoxyribonucleotide-oligospermine conjugates. Nat Protoc, 2, 1360-1367.


Bonnet, M. E., Erbacher, P., and Bolcato-Bellemin, A. L. (2008). Systemic Delivery of DNA or siRNA Mediated by Linear Polyethylenimine (L-PEI) Does Not Induce an Inflammatory Response. Pharm Res, (12):2972-82


Remaud S, López-Juárez SA, Bolcato-Bellemin AL, Neuberg P, Stock F, Bonnet ME, Ghaddab R, Clerget-Froidevaux MS, Pierre-Simons J, Erbacher P, Demeneix BA, Morvan-Dubois G.(2013). Inhibition of Sox2 Expression in the Adult Neural Stem Cell Niche In Vivo by Monocationic-based siRNA Delivery. Mol Ther Nucleic Acids 2: e89.

Hassani, Z., Lemkine, G. F., Erbacher, P., Palmier, K., Alfama, G., Giovannangeli, C., Behr, J. P., and Demeneix, B. A. (2005). Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels. J Gene Med 7, 198-207.


Louis, M. H., Dutoit, S., Denoux, Y., Erbacher, P., Deslandes, E., Behr, J. P., Gauduchon, P., and Poulain, L. (2006). Intraperitoneal linear polyethylenimine (L-PEI)-mediated gene delivery to ovarian carcinoma nodes in mice. Cancer Gene Ther 13, 367-374.


Lisziewicz, J., Trocio, J., Whitman, L., Varga, G., Xu, J., Bakare, N., Erbacher, P., Fox, C., Woodward, R., Markham, P., et al. (2005). DermaVir: a novel topical vaccine for HIV/AIDS. J Invest Dermatol 124, 160-169


Ndoye, A., Dolivet, G., Hogset, A., Leroux, A., Fifre, A., Erbacher, P., Berg, K., Behr, J. P., Guillemin, F., and Merlin, J. L. (2006). Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization. Mol Ther 13, 1156-1162.

Ndoye, A., Bouali, S., Dolivet, G., Leroux, A., Erbacher, P., Behr, J. P., Berg, K., Guillemin, F., and Merlin, J. L. (2004a). Sustained gene transfer and enhanced cell death following glucosylated-PEI-mediated p53 gene transfer with photochemical internalisation in p53-mutated head and neck carcinoma cells. Int J Oncol 25, 1575-1581.

Ndoye, A., Merlin, J. L., Leroux, A., Dolivet, G., Erbacher, P., Behr, J. P., Berg, K., and Guillemin, F. (2004b). Enhanced gene transfer and cell death following p53 gene transfer using photochemical internalisation of glucosylated PEI-DNA complexes. J Gene Med 6, 884-894.

Dolivet, G., Merlin, J. L., Barberi-Heyob, M., Ramacci, C., Erbacher, P., Parache, R. M., Behr, J. P., and Guillemin, F. (2002). In vivo growth inhibitory effect of iterative wild-type p53 gene transfer in human head and neck carcinoma xenografts using glucosylated polyethylenimine nonviral vector. Cancer Gene Ther 9, 708-714.


Arnold, A. S., Laporte, V., Dumont, S., Appert-Collin, A., Erbacher, P., Coupin, G., Levy, R., Poindron, P., and Gies, J. P. (2006). Comparing reagents for efficient transfection of human primary myoblasts: FuGENE 6, Effectene and ExGen 500. Fundam Clin Pharmacol 20, 81-89.

Mennesson, E., Erbacher, P., Kuzak, M., Kieda, C., Midoux, P., and Pichon, C. (2006). DNA/cationic polymer complex attachment on a human vascular endothelial cell monolayer exposed to a steady laminar flow. J Control Release 114, 389-397.

Mennesson, E., Erbacher, P., Piller, V., Kieda, C., Midoux, P., and Pichon, C. (2005). Transfection efficiency and uptake process of polyplexes in human lung endothelial cells: a comparative study in non-polarized and polarized cells. J Gene Med 7, 729-738.


Yu T., Liu X., Bolcato-Bellemin A.L., Wang Y., Liu C., Erbacher P., Qu F., Rocchi P., Behr J.P., and Peng L., (2012) An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo. Angew. Chem. Int. Ed., 51, 8478-8484.

Liu, X., Wu, J., Yammine, M., Zhou, J., Posocco, P., Viel, S., Liu, C., Ziarelli, F., Fermeglia, M., Pricl, S., Victorero, G., Nguyen, C., Erbacher, P., Behr, JP., and Peng L., (2011). Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus. Bioconjugate Chemistry,

Dobbs, W., Heinrich, B., Bourgogne, C., Donnio, B., Terazzi, E., Bonnet, M-E., Stock, F., Erbacher, P., Bolcato-Bellemin, A-L., and Douce, L., (2009). Mesomorphic imidazolium salts: new vectors for efficient siRNA transfection. JACS 131, 13338-46.

Pons, B., Mouhoubi, L., Adib, A., Godzina, P., Behr, J. P., and Zuber, G. (2006). Omega-Hydrazino linear polyethylenimine: a monoconjugation building block for nucleic acid delivery. Chembiochem 7, 303-309.

Zhou, J., Wu, J., Hafdi, N., Behr, J. P., Erbacher, P., and Peng, L. (2006). PAMAM dendrimers for efficient siRNA delivery and potent gene silencing. Chem Commun (Camb), 2362-2364.

Erbacher, P., Bettinger, T., Brion, E., Coll, J. L., Plank, C., Behr, J. P., and Remy, J. S. (2004). Genuine DNA/polyethylenimine (PEI) complexes improve transfection properties and cell survival. J Drug Target 12, 223-236.

Zaric, V., Weltin, D., Erbacher, P., Remy, J. S., Behr, J. P., and Stephan, D. (2004). Effective polyethylenimine-mediated gene transfer into human endothelial cells. J Gene Med 6, 176-184


Weiss, A.,  Neuberg, P., Philippot, S., Erbacher, P., and Weill, C. (2011). Intracellular peptide delivery using amphiphilic lipid-based formulations. Biotechnol Bioeng 30.

Weill, C., Biri, S., and Erbacher, P. (2008b). Cationic lipid-mediated intracellular delivery of antibodies into live cells. Biotechniques 44, Pvii-Pxi.7

Weill, C., Biri, S., Adib, A., and Erbacher, P. (2008a). A practical approach for intracellular protein delivery. Cytotechnology 56, 41-48.


Porte, M., Stock, F., and Horry, H. (2012). TGE for Recombinant Protein Production. GEN 32,5.


Williamson, J.F. (2008). Advances and perspectives in intracellular biomolecule delivery. Pharmaceutical Technology Europe, July 2008, p. 43-46.

Zuber, G., Dauty, E., Nothisen, M., Belguise, P., and Behr, J. P. (2001). Towards synthetic viruses. Advanced Drug Delivery Reviews 52, 245-253